The Journal of Experimental Medicine
Keystone Symposia
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 May 14 2007; 204 (5)

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To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.
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IN THIS ISSUE:Back

IN THIS ISSUE [PDF]
Keeping track of AID [Full Text]  
Avoiding fetal loss [Full Text]  
B cells blunt neonatal immunity [Full Text]  
Breast cancer hijacks dendritic cells [Full Text]  
Lipid tails dictate NKT cell response [Full Text]  

 

FROM THE ARCHIVE:Back

FROM THE ARCHIVE [PDF]
Interleukin-12: A master regulator [Abstract] [Full Text]  

 

BRIEF DEFINITIVE REPORTS:Back

NF90 regulates inducible IL-2 gene expression in T cells
Lingfang Shi, Wayne R. Godfrey, Joseph Lin, Guohua Zhao, and Peter N. Kao
J. Exp. Med. 2007 204: 971-977. Published online Apr 30 2007, 10.1084/jem.20052078. [Abstract] [Full Text] [PDF]  

Increased frequencies of CD4+CD25high regulatory T cells in acute dengue infection
Kerstin Lühn, Cameron P. Simmons, Edward Moran, Nguyen Thi Phuong Dung, Tran Nguyen Bich Chau, Nguyen Than Ha Quyen, Le Thi Thu Thao, Tran Van Ngoc, Nguyen Minh Dung, Bridget Wills, Jeremy Farrar, Andrew J. McMichael, Tao Dong, and Sarah Rowland-Jones
J. Exp. Med. 2007 204: 979-985. Published online Apr 23 2007, 10.1084/jem.20061381. [Abstract] [Full Text] [PDF] [Supplemental Material index]  

Type I interferon signaling is required for activation of the inflammasome during Francisella infection
Thomas Henry, Anna Brotcke, David S. Weiss, Lucinda J. Thompson, and Denise M. Monack
J. Exp. Med. 2007 204: 987-994. Published online Apr 23 2007, 10.1084/jem.20062665. [Abstract] [Full Text] [PDF] [Supplemental Material index]  

Identification of an IL-17–producing NK1.1neg iNKT cell population involved in airway neutrophilia
Marie-Laure Michel, Alexandre Castro Keller, Christophe Paget, Masakazu Fujio, François Trottein, Paul B. Savage, Chi-Huey Wong, Elke Schneider, Michel Dy, and Maria C. Leite-de-Moraes
J. Exp. Med. 2007 204: 995-1001. Published online Apr 30 2007, 10.1084/jem.20061551. [Abstract] [Full Text] [PDF] [Supplemental Material Index]  

Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis
Simone Difilippantonio, Arkady Celeste, Michael J. Kruhlak, Youngsoo Lee, Michael J. Difilippantonio, Lionel Feigenbaum, Stephen P. Jackson, Peter J. McKinnon, and André Nussenzweig
J. Exp. Med. 2007 204: 1003-1011. Published online May 7 2007, 10.1084/jem.20070319. [Abstract] [Full Text] [PDF] [Supplemental Material Index]  

 

ARTICLES:Back

Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor–mediated immune responses but not in TCR signaling
Tatsukata Kawagoe, Shintaro Sato, Andreas Jung, Masahiro Yamamoto, Kosuke Matsui, Hiroki Kato, Satoshi Uematsu, Osamu Takeuchi, and Shizuo Akira
J. Exp. Med. 2007 204: 1013-1024. Published online May 7 2007, 10.1084/jem.20061523. [Abstract] [Full Text] [PDF] [Supplemental Material Index]  

A critical role for IRAK4 kinase activity in Toll-like receptor–mediated innate immunity
Tae Whan Kim, Kirk Staschke, Katarzyna Bulek, Jianhong Yao, Kristi Peters, Keun-Hee Oh, Yvonne Vandenburg, Hui Xiao, Wen Qian, Tom Hamilton, Booki Min, Ganes Sen, Raymond Gilmour, and Xiaoxia Li
J. Exp. Med. 2007 204: 1025-1036. Published online Apr 30 2007, 10.1084/jem.20061825. [Abstract] [Full Text] [PDF]  

Breast cancer instructs dendritic cells to prime interleukin 13–secreting CD4+ T cells that facilitate tumor development
Caroline Aspord, Alexander Pedroza-Gonzalez, Mike Gallegos, Sasha Tindle, Elizabeth C. Burton, Dan Su, Florentina Marches, Jacques Banchereau, and A. Karolina Palucka
J. Exp. Med. 2007 204: 1037-1047. Published online Apr 16 2007, 10.1084/jem.20061120. [Abstract] [Full Text] [PDF]  

Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothers
Rashmi Sood, Mark Zogg, Randal J. Westrick, Yi-he Guo, Edward J. Kerschen, Guillermina Girardi, Jane E. Salmon, Shaun R. Coughlin, and Hartmut Weiler
J. Exp. Med. 2007 204: 1049-1056. Published online Apr 16 2007, 10.1084/jem.20062566. [Abstract] [Full Text] [PDF]  

Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis
Ludovic Arnold, Adeline Henry, Françoise Poron, Yasmine Baba-Amer, Nico van Rooijen, Anne Plonquet, Romain K. Gherardi, and Bénédicte Chazaud
J. Exp. Med. 2007 204: 1057-1069. Published online May 7 2007, 10.1084/jem.20070075. [Abstract] [Full Text] [PDF]  

Expression of lymphotoxin-{alpha}ß on antigen-specific T cells is required for DC function
Leslie E. Summers-deLuca, Douglas D. McCarthy, Bojana Cosovic, Lesley A. Ward, Calvin C. Lo, Stefanie Scheu, Klaus Pfeffer, and Jennifer L. Gommerman
J. Exp. Med. 2007 204: 1071-1081. Published online Apr 23 2007, 10.1084/jem.20061968. [Abstract] [Full Text] [PDF] [Supplemental Material index]  

Semaphorin 7A plays a critical role in TGF-ß1–induced pulmonary fibrosis
Hye-Ryun Kang, Chun Geun Lee, Robert J. Homer, and Jack A. Elias
J. Exp. Med. 2007 204: 1083-1093. Published online May 7 2007, 10.1084/jem.20061273. [Abstract] [Full Text] [PDF] [Supplemental Material Index]  

A subset of dendritic cells induces CD4+ T cells to produce IFN-{gamma} by an IL-12–independent but CD70-dependent mechanism in vivo
Helena Soares, HaeNa Waechter, Nicholas Glaichenhaus, Evelyne Mougneau, Hideo Yagita, Olga Mizenina, Diana Dudziak, Michel C. Nussenzweig, and Ralph M. Steinman
J. Exp. Med. 2007 204: 1095-1106. Published online Apr 16 2007, 10.1084/jem.20070176. [Abstract] [Full Text] [PDF] [Supplemental Material Index]  

Type I interferons protect neonates from acute inflammation through interleukin 10–producing B cells
Xiaoming Zhang, Edith Deriaud, Xinan Jiao, Deborah Braun, Claude Leclerc, and Richard Lo-Man
J. Exp. Med. 2007 204: 1107-1118. Published online May 7 2007, 10.1084/jem.20062013. [Abstract] [Full Text] [PDF] [Supplemental Material Index]  

Mature natural killer cell and lymphoid tissue–inducing cell development requires Id2-mediated suppression of E protein activity
Markus D. Boos, Yoshifumi Yokota, Gerard Eberl, and Barbara L. Kee
J. Exp. Med. 2007 204: 1119-1130. Published online Apr 23 2007, 10.1084/jem.20061959. [Abstract] [Full Text] [PDF]  

The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation
Corinna McCarthy, Dawn Shepherd, Sebastian Fleire, Victoria S. Stronge, Michael Koch, Petr A. Illarionov, Giovanna Bossi, Mariolina Salio, Galit Denkberg, Faye Reddington, Andrea Tarlton, B. Gopal Reddy, Richard R. Schmidt, Yoram Reiter, Gillian M. Griffiths, P. Anton van der Merwe, Gurdyal S. Besra, E. Yvonne Jones, Facundo D. Batista, and Vincenzo Cerundolo
J. Exp. Med. 2007 204: 1131-1144. Published online May 7 2007, 10.1084/jem.20062342. [Abstract] [Full Text] [PDF] [Supplemental Material Index]  

Regulation of AID expression in the immune response
Elizabeth E. Crouch, Zhiyu Li, Makiko Takizawa, Stefan Fichtner-Feigl, Polyxeni Gourzi, Carolina Montaño, Lionel Feigenbaum, Patrick Wilson, Siegfried Janz, F. Nina Papavasiliou, and Rafael Casellas
J. Exp. Med. 2007 204: 1145-1156. Published online Apr 23 2007, 10.1084/jem.20061952. [Abstract] [Full Text] [PDF] [Supplemental Material index]  

Activation-induced cytidine deaminase acts as a mutator in BCR-ABL1–transformed acute lymphoblastic leukemia cells
Niklas Feldhahn, Nadine Henke, Kai Melchior, Cihangir Duy, Bonaventure Ndikung Soh, Florian Klein, Gregor von Levetzow, Bernd Giebel, Aihong Li, Wolf-Karsten Hofmann, Hassan Jumaa, and Markus Müschen
J. Exp. Med. 2007 204: 1157-1166. Published online May 7 2007, 10.1084/jem.20062662. [Abstract] [Full Text] [PDF] [Supplemental Material Index]  

CCR7 ligands control basal T cell motility within lymph node slices in a phosphoinositide 3–kinase– independent manner
François Asperti-Boursin, Eliana Real, Georges Bismuth, Alain Trautmann, and Emmanuel Donnadieu
J. Exp. Med. 2007 204: 1167-1179. Published online May 7 2007, 10.1084/jem.20062079. [Abstract] [Full Text] [PDF] [Supplemental Material Index]  

Lymphomas can develop from B cells chronically helped by idiotype-specific T cells
Michael M. Zangani, Marianne Frøyland, Gao Yue Qiu, Leonardo A. Meza-Zepeda, Jeffery L. Kutok, Keith M. Thompson, Ludvig A. Munthe, and Bjarne Bogen
J. Exp. Med. 2007 204: 1181-1191. Published online May 7 2007, 10.1084/jem.20061220. [Abstract] [Full Text] [PDF] [Supplemental Material Index]  

CD8 single-cell gene coexpression reveals three different effector types present at distinct phases of the immune response
António Peixoto, César Evaristo, Ivana Munitic, Marta Monteiro, Alain Charbit, Benedita Rocha, and Henrique Veiga-Fernandes
J. Exp. Med. 2007 204: 1193-1205. Published online May 7 2007, 10.1084/jem.20062349. [Abstract] [Full Text] [PDF] [Supplemental Material Index]  

A primary immunodeficiency characterized by defective immunoglobulin class switch recombination and impaired DNA repair
Sophie Péron, Qiang Pan-Hammarström, Kohsuke Imai, Likun Du, Nadine Taubenheim, Ozden Sanal, Laszlo Marodi, Anne Bergelin-Besançon, Malika Benkerrou, Jean-Pierre de Villartay, Alain Fischer, Patrick Revy, and Anne Durandy
J. Exp. Med. 2007 204: 1207-1216. Published online May 7 2007, 10.1084/jem.20070087. [Abstract] [Full Text] [PDF]  

Cytomegalovirus exploits IL-10–mediated immune regulation in the salivary glands
Ian R. Humphreys, Carl de Trez, April Kinkade, Chris A. Benedict, Michael Croft, and Carl F. Ware
J. Exp. Med. 2007 204: 1217-1225. Published online May 7 2007, 10.1084/jem.20062424. [Abstract] [Full Text] [PDF] [Supplemental Material Index]  

Lysosomal integral membrane protein 2 is a novel component of the cardiac intercalated disc and vital for load-induced cardiac myocyte hypertrophy
Blanche Schroen, Joost J. Leenders, Arie van Erk, Anne T. Bertrand, Mirjam van Loon, Rick E. van Leeuwen, Nard Kubben, Rudy F. Duisters, Mark W. Schellings, Ben J. Janssen, Jacques J. Debets, Michael Schwake, Morten A. Høydal, Stephane Heymans, Paul Saftig, and Yigal M. Pinto
J. Exp. Med. 2007 204: 1227-1235. Published online May 7 2007, 10.1084/jem.20070145. [Abstract] [Full Text] [PDF] [Supplemental Material Index]  

 

CORRECTIONS:Back

Roles of peroxiredoxin II in the regulation of proinflammatory responses to LPS and protection against endotoxin-induced lethal shock
Chul-Su Yang, Dong-Seok Lee, Chang-Hwa Song, Se-Jin An, Shengjin Li, Jin-Man Kim, Cuk Seong Kim, Dae Goon Yoo, Byeong Hwa Jeon, Hee-Young Yang, Tae-Hoon Lee, Zee-Won Lee, Jamel El-Benna, Dae-Yeul Yu, and Eun-Kyeong Jo
J. Exp. Med. 2007 204: 1237. Published online May 7 2007, 10.1084/jem.20061849041807c. [Full Text] [PDF]  

 

FROM THE JCB:Back

In macrophages, HIV-1 assembles into an intracellular plasma membrane domain containing the tetraspanins CD81, CD9, and CD53
Magdalena Deneka, Annegret Pelchen-Matthews, Rahel Byland, Ezequiel Ruiz-Mateos, and Mark Marsh [Full Text]  

The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling
Melanie M. Brinkmann, Eric Spooner, Kasper Hoebe, Bruce Beutler, Hidde L. Ploegh, and You-Me Kim [Full Text]  

Vascular endothelial growth factor can signal through platelet-derived growth factor receptors
Stephen G. Ball, C. Adrian Shuttleworth, and Cay M. Kielty [Full Text]  

Genetic alteration of endothelial heparan sulfate selectively inhibits tumor angiogenesis
Mark M. Fuster, Lianchun Wang, Janice Castagnola, Lyudmila Sikora, Krisanavane Reddi, Phillip H.A. Lee, Katherine A. Radek, Manuela Schuksz, Joseph R. Bishop, Richard L. Gallo, P. Sriramarao, and Jeffrey D. Esko [Full Text]  

To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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