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Cover picture: Cover picture: Borrelia burgdorferi (green), the spirochetal agent of Lyme disease, is tightly associated with tick midgut tissue (red) during natural colonization of its arthropod vector (left). When the OspA/B operon, encoding outer surface (lipo)proteins A (OspA) and B (OspB), was inactivated in B. burgdorferi , the mutant spirochetes were no longer able to colonize and survive within the tick vector (right). See the related article by Yang et al. (pp. 641-606).
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