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Cover picture: Erythroid cells isolated from fetal liver at embryonic day 16.5 (left panels) and spleen with stomach (right panels) of wild-type control mice (top panels) and mice deficient in the novel antiapoptotic molecule Anamorsin (bottom panels). The erythroblasts were larger in Anamorsin-/- embryos than in Anamorsin+/+ embryos, and more mature erythroblasts (i.e., polychromatic and orthochromatic erythroblasts) were markedly decreased in Anamorsin-/- embryos. The spleen of Anamorsin-/- embryo was remarkably smaller than that of Anamorsin+/+ embryo and appeared scarce. Anamorsin-/- mice die in late gestation due to defective hematopoiesis in the fetal liver. See related article by Shibayama et al., pp. 581-592.
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