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COVER PICTURE:
A critical event in the initiation of an immune response is the encounter of
Ag-specific T cells with DCs that present the Ag of interest. Imaging of
initial T cell activation clusters reveals the strategy that the immune system
has developed for the two rare cells to find each other in the midst of irrelevant
other cells in LNs. Skin-derived DCs preferentially home in the vicinity of high
endothelial venules (HEVs), the entry route of T cells into the paracortex,
where they efficiently scan all incoming T cells and selectively retain those
specific for the MHC-peptide complexes the DCs present.
The picture shows clustering of Ag-specific T cells (red) near HEVs (blue) in the outer
para-cortex in the proximity of the B cell zone (green) in Ag draining LNs.
See related article by Bajinoff et al., pp.
715-724.
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