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The Journal of Experimental Medicine
196
3
Bronchial epithelial cells of the adult human lung express the major histocompatibility complex class I-related Fc receptor, FcRn. FcRn acts as a transepithelial trafficking receptor for IgG that mediates absorption of the intact immunoglobulin from lumenal secretions. Such receptor-mediated transport explains a mechanism by which IgG may act in immune surveillance to retrieve lumenal antigens from mucosal surfaces for processing in the lamina propria or systemically. See related article by Spiekermann et al., pp. 303-310.
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