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The Journal of Experimental Medicine 195 2 The role of the RelA in the development of secondary lymphoid organs has not been possible to determine as RelA-deficient mice die at embryonic day 15. However, mice deficient for both RelA and TNFR1 are viable and reveal an essential role for RelA in the development of lymph nodes, Peyerıs patches, and spleen. The cover images show the microarchitecture of spleens from wild-type (left) and TNFR1/RelA­deficient (right) mice. TNFR1/RelA mutant spleens have severely reduced T and B cell zones (top: CD3 in purple and B220 in brown to mark T and B cell zones, respectively), and lack follicular dendritic cells (bottom: CR1 in purple) and germinal centers (bottom: PNA in brown). See related article by Alcamo et al., pp. 233-244
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