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The Journal of Experimental Medicine
195
11
Eosinophil development requires transcription factor GATA-1. Bone marrow of wild-type mice expressing an interleukin 5 transgene contains numerous eosinophils (left). In contrast, mice with a gene-targeted deletion of a high-affinity GATA-binding site in the GATA-1 gene promoter have a specific failure to produce eosinophils (right). See related article by Yu et al., pp.
1387-1395.
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