About the Cover
The Journal of Experimental Medicine
193
11
Regulatory T cells can be generated during T cell differentiation in the thymus or in the periphery. CD4+CD25+ T cells represent ~10% of mature CD4+CD8- single-positive thymocytes. Upon recognition of their target self-antigen in the thymus, they undergo an alternative selection process that renders them anergic and suppressive. Exposure of CD4+CD25- T cells in the periphery to antigen presented in the context of limited costimulatory signals (immature dendritic cells [iDCs] or interleukin [IL]-10) also results in the induction of suppressor T cells. Both populations can inhibit the activation of effector T cells by cell contactdependent or cytokine-mediated mechanisms. See Commentary in this issue by Shevach, pp.
F41-F45, and related articles by Jonuleit et al., Levings et al., Dieckmann et al., and Taylor et al., pp.
1285-1294,
1295-1301,
1303-1310, and
1311-1317, respectively. Cover design by Bob Crimi.
[Table of Contents]
