About the Cover
Cover picture: Molecular model for recognition of a lipid antigen-CD1 complex by a T cell receptor. The hydrophobic CD1 antigen-binding groove is visualized from the side between the 
1 and 2 helices. The mycolic acid-specific, CD1b-restricted DN1 TCR V and
V
complementarity determining loops (blue) are modeled over human CD1b (red). Lipid antigen acyl chain tails are thought to bind in the
CD1 hydrophobic groove, whereas the polar heads of amphipathic lipid and glycolipid antigens are predicted to be exposed at the solvent
interface with the CD1 helices. The side chains of residues R97 and R98 in the DN1 TCR- CDR3 region (yellow) project into the hydrophobic cleft where the polar moieties of the lipid antigen are hypothesized to be located. See related article in this issue by Grant et al., pp. 195-205.
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