J. Exp. Med., Volume 188, Number 10, November 16, 1998 1831-1839

Overexpression of Natural Killer T Cells Protects V14-J281 Transgenic Nonobese Diabetic Mice against Diabetes

By Agnès Lehuen,^* Olivier Lantz,^* Lucie Beaudoin,^* Véronique Laloux,^* Claude Carnaud,^* Albert Bendelac, Jean-François Bach,^* and Renato C. Monteiro^*

From ^* INSERM U 25, Hôpital Necker, 75743 Paris, France; and the  Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544

Progression to destructive insulitis in nonobese diabetic (NOD) mice is linked to the failure of regulatory cells, possibly involving T helper type 2 (Th2) cells. Natural killer (NK) T cells might be involved in diabetes, given their deficiency in NOD mice and the prevention of diabetes by adoptive transfer of / double-negative thymocytes. Here, we evaluated the role of NK T cells in diabetes by using transgenic NOD mice expressing the T cell antigen receptor (TCR)  chain V14-J281 characteristic of NK T cells. Precise identification of NK1.1⁺ T cells was based on out-cross with congenic NK1.1 NOD mice. All six transgenic lines showed, to various degrees, elevated numbers of NK1.1⁺ T cells, enhanced production of interleukin (IL)-4, and increased levels of serum immunoglobulin E. Only the transgenic lines with the largest numbers of NK T cells and the most vigorous burst of IL-4 production were protected from diabetes. Transfer and cotransfer experiments with transgenic splenocytes demonstrated that V14-J281 transgenic NOD mice, although protected from overt diabetes, developed a diabetogenic T cell repertoire, and that NK T cells actively inhibited the pathogenic action of T cells. These results indicate that the number of NK T cells strongly influences the development of diabetes.

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• Sandberg, J. K., Stoddart, C. A., Brilot, F., Jordan, K. A., Nixon, D. F. (2004). Development of innate CD4+ {alpha}-chain variable gene segment 24 (V{alpha}24) natural killer T cells in the early human fetal thymus is regulated by IL-7. Proc. Natl. Acad. Sci. USA 101: 7058-7063 [Abstract] [Full Text]  
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• Matsuki, N., Stanic, A. K., Embers, M. E., Van Kaer, L., Morel, L., Joyce, S. (2003). Genetic Dissection of V{alpha}14J{alpha}18 Natural T Cell Number and Function in Autoimmune-Prone Mice. J. Immunol. 170: 5429-5437 [Abstract] [Full Text]  
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• Capone, M., Cantarella, D., Schumann, J., Naidenko, O. V., Garavaglia, C., Beermann, F., Kronenberg, M., Dellabona, P., MacDonald, H. R., Casorati, G. (2003). Human Invariant V{alpha}24-J{alpha}Q TCR Supports the Development of CD1d-Dependent NK1.1+ and NK1.1- T Cells in Transgenic Mice. J. Immunol. 170: 2390-2398 [Abstract] [Full Text]  
• Williams, K. L., Zullo, A. J., Kaplan, M. H., Brutkiewicz, R. R., Deppmann, C. D., Vinson, C., Taparowsky, E. J. (2003). BATF Transgenic Mice Reveal a Role for Activator Protein-1 in NKT Cell Development. J. Immunol. 170: 2417-2426 [Abstract] [Full Text]  
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• Oikawa, Y., Shimada, A., Yamada, S., Motohashi, Y., Nakagawa, Y., Irie, J.-i., Maruyama, T., Saruta, T. (2002). High Frequency of V{alpha}24+ V{beta}11+ T-Cells Observed in Type 1 Diabetes. Diabetes Care 25: 1818-1823 [Abstract] [Full Text]  
• Faunce, D. E., Stein-Streilein, J. (2002). NKT Cell-Derived RANTES Recruits APCs and CD8+ T Cells to the Spleen During the Generation of Regulatory T Cells in Tolerance. J. Immunol. 169: 31-38 [Abstract] [Full Text]  
• Sandberg, J. K., Fast, N. M., Palacios, E. H., Fennelly, G., Dobroszycki, J., Palumbo, P., Wiznia, A., Grant, R. M., Bhardwaj, N., Rosenberg, M. G., Nixon, D. F. (2002). Selective Loss of Innate CD4+ V{alpha}24 Natural Killer T Cells in Human Immunodeficiency Virus Infection. J. Virol. 76: 7528-7534 [Abstract] [Full Text]  
• Mars, L. T., Laloux, V., Goude, K., Desbois, S., Saoudi, A., Van Kaer, L., Lassmann, H., Herbelin, A., Lehuen, A., Liblau, R. S. (2002). Cutting Edge: V{alpha}14-J{alpha}281 NKT Cells Naturally Regulate Experimental Autoimmune Encephalomyelitis in Nonobese Diabetic Mice. J. Immunol. 168: 6007-6011 [Abstract] [Full Text]  
• Laloux, V., Beaudoin, L., Ronet, C., Lehuen, A. (2002). Phenotypic and Functional Differences Between NKT Cells Colonizing Splanchnic and Peripheral Lymph Nodes. J. Immunol. 168: 3251-3258 [Abstract] [Full Text]  
• Lee, P. T., Benlagha, K., Teyton, L., Bendelac, A. (2002). Distinct Functional Lineages of Human V{alpha}24 Natural Killer T Cells. J. Exp. Med. 195: 637-641 [Abstract] [Full Text]  
• Mempel, M., Ronet, C., Suarez, F., Gilleron, M., Puzo, G., Van Kaer, L., Lehuen, A., Kourilsky, P., Gachelin, G. (2002). Natural Killer T Cells Restricted by the Monomorphic MHC Class 1b CD1d1 Molecules Behave Like Inflammatory Cells. J. Immunol. 168: 365-371 [Abstract] [Full Text]  
• Yang, Y., Bao, M., Yoon, J.-W. (2001). Intrinsic Defects in the T-Cell Lineage Results in Natural Killer T-Cell Deficiency and the Development of Diabetes in the Nonobese Diabetic Mouse. Diabetes 50: 2691-2699 [Abstract] [Full Text]  
• Hobbs, J. A., Cho, S., Roberts, T. J., Sriram, V., Zhang, J., Xu, M., Brutkiewicz, R. R. (2001). Selective Loss of Natural Killer T Cells by Apoptosis following Infection with Lymphocytic Choriomeningitis Virus. J. Virol. 75: 10746-10754 [Abstract] [Full Text]  
• Naumov, Y. N., Bahjat, K. S., Gausling, R., Abraham, R., Exley, M. A., Koezuka, Y., Balk, S. B., Strominger, J. L., Clare-Salzer, M., Wilson, S. B. (2001). Activation of CD1d-restricted T cells protects NOD mice from developing diabetes by regulating dendritic cell subsets. Proc. Natl. Acad. Sci. USA 10.1073/pnas.251531798v1 [Abstract] [Full Text]  
• Maeda, M., Lohwasser, S., Yamamura, T., Takei, F. (2001). Regulation of NKT Cells by Ly49: Analysis of Primary NKT Cells and Generation of NKT Cell Line. J. Immunol. 167: 4180-4186 [Abstract] [Full Text]  
• Wang, B., Geng, Y.-B., Wang, C.-R. (2001). CD1-restricted NK T Cells Protect Nonobese Diabetic Mice from Developing Diabetes. J. Exp. Med. 194: 313-320 [Abstract] [Full Text]  
• Hammond, K. J. L., Pellicci, D. G., Poulton, L. D., Naidenko, O. V., Scalzo, A. A., Baxter, A. G., Godfrey, D. I. (2001). CD1d-Restricted NKT Cells: An Interstrain Comparison. J. Immunol. 167: 1164-1173 [Abstract] [Full Text]  
• Poulton, L. D., Smyth, M. J., Hawke, C. G., Silveira, P., Shepherd, D., Naidenko, O. V., Godfrey, D. I., Baxter, A. G. (2001). Cytometric and functional analyses of NK and NKT cell deficiencies in NOD mice. Int Immunol 13: 887-896 [Abstract] [Full Text]  
• Shi, F.-D., Flodstrom, M., Balasa, B., Kim, S. H., Van Gunst, K., Strominger, J. L., Wilson, S. B., Sarvetnick, N. (2001). Germ line deletion of the CD1 locus exacerbates diabetes in the NOD mouse. Proc. Natl. Acad. Sci. USA 98: 6777-6782 [Abstract] [Full Text]  
• Laloux, V., Beaudoin, L., Jeske, D., Carnaud, C., Lehuen, A. (2001). NK T Cell-Induced Protection Against Diabetes in V{{alpha}}14-J{{alpha}}281 Transgenic Nonobese Diabetic Mice Is Associated with a Th2 Shift Circumscribed Regionally to the Islets and Functionally to Islet Autoantigen. J. Immunol. 166: 3749-3756 [Abstract] [Full Text]  
• Trobonjaca, Z., Leithauser, F., Moller, P., Bluethmann, H., Koezuka, Y., MacDonald, H. R., Reimann, J. (2001). MHC-II-Independent CD4+ T Cells Induce Colitis in Immunodeficient RAG-/- Hosts. J. Immunol. 166: 3804-3812 [Abstract] [Full Text]  
• Carnaud, C., Gombert, J.-M., Donnars, O., Garchon, H.-J., Herbelin, A. (2001). Protection Against Diabetes and Improved NK/NKT Cell Performance in NOD.NK1.1 Mice Congenic at the NK Complex. J. Immunol. 166: 2404-2411 [Abstract] [Full Text]  
• Seino, K.-i., Fukao, K., Muramoto, K., Yanagisawa, K., Takada, Y., Kakuta, S., Iwakura, Y., Van Kaer, L., Takeda, K., Nakayama, T., Taniguchi, M., Bashuda, H., Yagita, H., Okumura, K. (2001). Requirement for natural killer T (NKT) cells in the induction of allograft tolerance. Proc. Natl. Acad. Sci. USA 10.1073/pnas.041608298v1 [Abstract] [Full Text]  
• del C. Salamone, M., Rabinovich, G. A., Mendiguren, A. K., Salamone, G. V., Fainboim, L. (2001). Activation-induced expression of CD1d antigen on mature T cells. J. Leukoc. Biol. 69: 207-214 [Abstract] [Full Text]  
• Ronet, C., Mempel, M., Thieblemont, N., Lehuen, A., Kourilsky, P., Gachelin, G. (2001). Role of the Complementarity-Determining Region 3 (CDR3) of the TCR-{{beta}} Chains Associated with the V{{alpha}}14 Semi-Invariant TCR {{alpha}}-Chain in the Selection of CD4+ NK T Cells. J. Immunol. 166: 1755-1762 [Abstract] [Full Text]  
• Leite-de-Moraes, M. C., Hameg, A., Pacilio, M., Koezuka, Y., Taniguchi, M., Van Kaer, L., Schneider, E., Dy, M., Herbelin, A. (2001). IL-18 Enhances IL-4 Production by Ligand-Activated NKT Lymphocytes: A Pro-Th2 Effect of IL-18 Exerted Through NKT Cells. J. Immunol. 166: 945-951 [Abstract] [Full Text]  
• Faunce, D. E., Sonoda, K.-H., Stein-Streilein, J. (2001). MIP-2 Recruits NKT Cells to the Spleen During Tolerance Induction. J. Immunol. 166: 313-321 [Abstract] [Full Text]  
• Pal, E., Tabira, T., Kawano, T., Taniguchi, M., Miyake, S., Yamamura, T. (2001). Costimulation-Dependent Modulation of Experimental Autoimmune Encephalomyelitis by Ligand Stimulation of V{{alpha}}14 NK T Cells. J. Immunol. 166: 662-668 [Abstract] [Full Text]  
• Araujo, L. M., Puel, A., Gouarin, C., Hameg, A., Mevel, J.-C., Koezuka, Y., Bach, J.-F., Mouton, D., Herbelin, A. (2000). NKT lymphocyte ontogeny and function are impaired in low antibody-producer Biozzi mice: gene mapping in the interval-specific congenic strains raised for immunomodulatory genes. Int Immunol 12: 1613-1622 [Abstract] [Full Text]  
• Yang, O. O., Racke, F. K., Nguyen, P. T., Gausling, R., Severino, M. E., Horton, H. F., Byrne, M. C., Strominger, J. L., Wilson, S. B. (2000). CD1d on Myeloid Dendritic Cells Stimulates Cytokine Secretion from and Cytolytic Activity of V{alpha}24J{alpha}Q T Cells: A Feedback Mechanism for Immune Regulation. J. Immunol. 165: 3756-3762 [Abstract] [Full Text]  
• Bonish, B., Jullien, D., Dutronc, Y., Huang, B. B., Modlin, R., Spada, F. M., Porcelli, S. A., Nickoloff, B. J. (2000). Overexpression of CD1d by Keratinocytes in Psoriasis and CD1d-Dependent IFN-{gamma} Production by NK-T Cells. J. Immunol. 165: 4076-4085 [Abstract] [Full Text]  
• MacDonald, H. R. (2000). CD1d-Glycolipid Tetramers: A New Tool to Monitor Natural Killer T Cells in Health and Disease. J. Exp. Med. 192: F15-F20 [Full Text]  
• Silver, E. T., Gong, D.-E., Chang, C. S., Amrani, A., Santamaria, P., Kane, K. P. (2000). Ly-49P Activates NK-Mediated Lysis by Recognizing H-2Dd 1. J. Immunol. 165: 1771-1781 [Abstract] [Full Text]  
• Gonzalez-Aseguinolaza, G., de Oliveira, C., Tomaska, M., Hong, S., Bruna-Romero, O., Nakayama, T., Taniguchi, M., Bendelac, A., Van Kaer, L., Koezuka, Y., Tsuji, M. (2000). alpha -Galactosylceramide-activated Valpha 14 natural killer T cells mediate protection against murine malaria. Proc. Natl. Acad. Sci. USA 97: 8461-8466 [Abstract] [Full Text]  
• Wilson, S. B., Kent, S. C., Horton, H. F., Hill, A. A., Bollyky, P. L., Hafler, D. A., Strominger, J. L., Byrne, M. C. (2000). Multiple differences in gene expression in regulatory Valpha 24Jalpha Q T cells from identical twins discordant for type I diabetes. Proc. Natl. Acad. Sci. USA 10.1073/pnas.120161297v1 [Abstract] [Full Text]  
• Olivares-Villagomez, D., Wensky, A. K., Wang, Y., Lafaille, J. J. (2000). Repertoire Requirements of CD4+ T Cells That Prevent Spontaneous Autoimmune Encephalomyelitis. J. Immunol. 164: 5499-5507 [Abstract] [Full Text]  
• Takahashi, T., Nieda, M., Koezuka, Y., Nicol, A., Porcelli, S. A., Ishikawa, Y., Tadokoro, K., Hirai, H., Juji, T. (2000). Analysis of Human V{alpha}24+ CD4+ NKT Cells Activated by {alpha}-Glycosylceramide-Pulsed Monocyte-Derived Dendritic Cells. J. Immunol. 164: 4458-4464 [Abstract] [Full Text]  
• Ito, K., Karasawa, M., Kawano, T., Akasaka, T., Koseki, H., Akutsu, Y., Kondo, E., Sekiya, S., Sekikawa, K., Harada, M., Yamashita, M., Nakayama, T., Taniguchi, M. (2000). Involvement of decidual Valpha 14 NKT cells in abortion. Proc. Natl. Acad. Sci. USA 97: 740-744 [Abstract] [Full Text]  
• Kaneko, Y., Harada, M., Kawano, T., Yamashita, M., Shibata, Y., Gejyo, F., Nakayama, T., Taniguchi, M. (2000). Augmentation of V{alpha}14 NKT Cell-mediated Cytotoxicity by Interleukin 4 in an Autocrine Mechanism Resulting in the Development of Concanavalin A-induced Hepatitis. J. Exp. Med. 191: 105-114 [Abstract] [Full Text]  
• Lepault, F., Gagnerault, M. C. (2000). Characterization of Peripheral Regulatory CD4+ T Cells That Prevent Diabetes Onset in Nonobese Diabetic Mice. J. Immunol. 164: 240-247 [Abstract] [Full Text]  
• Zeng, D., Gazit, G., Dejbakhsh-Jones, S., Balk, S. P., Snapper, S., Taniguchi, M., Strober, S. (1999). Heterogeneity of NK1.1+ T Cells in the Bone Marrow: Divergence from the Thymus. J. Immunol. 163: 5338-5345 [Abstract] [Full Text]  
• Hong, S., Van Kaer, L. (1999). Immune Privilege: Keeping an Eye on Natural Killer T Cells. J. Exp. Med. 190: 1197-1200 [Full Text]  
• Carnaud, C., Lee, D., Donnars, O., Park, S.-H., Beavis, A., Koezuka, Y., Bendelac, A. (1999). Cutting Edge: Cross-Talk Between Cells of the Innate Immune System: NKT Cells Rapidly Activate NK Cells. J. Immunol. 163: 4647-4650 [Abstract] [Full Text]  
• Falcone, M., Yeung, B., Tucker, L., Rodriguez, E., Sarvetnick, N. (1999). A Defect in Interleukin 12–induced Activation and Interferon {gamma} Secretion of Peripheral Natural Killer T Cells in Nonobese Diabetic Mice Suggests New Pathogenic Mechanisms for Insulin-dependent Diabetes Mellitus. J. Exp. Med. 190: 963-972 [Abstract] [Full Text]  
• Benlagha, K., Weiss, A., Beavis, A., Teyton, L., Bendelac, A. (1999). In Vivo Identification of Glycolipid Antigen-specific T Cells Using Fluorescent CD1d Tetramers. J. Exp. Med. 191: 1895-1904 [Abstract] [Full Text]  
• Launay, P., Grossetete, B., Arcos-Fajardo, M., Gaudin, E., Torres, S. P., Beaudoin, L., Patey-Mariaud de Serre, N., Lehuen, A., Monteiro, R. C. (1999). Fc{alpha} Receptor (CD89) Mediates the Development of Immunoglobulin A (IgA) Nephropathy (Berger's Disease): Evidence for Pathogenic Soluble Receptor-IgA Complexes in Patients and CD89 Transgenic Mice. J. Exp. Med. 191: 1999-2010 [Abstract] [Full Text]  
• Seino, K.-i., Fukao, K., Muramoto, K., Yanagisawa, K., Takada, Y., Kakuta, S., Iwakura, Y., Van Kaer, L., Takeda, K., Nakayama, T., Taniguchi, M., Bashuda, H., Yagita, H., Okumura, K. (2001). Requirement for natural killer T (NKT) cells in the induction of allograft tolerance. Proc. Natl. Acad. Sci. USA 98: 2577-2581 [Abstract] [Full Text]  
• Wilson, S. B., Kent, S. C., Horton, H. F., Hill, A. A., Bollyky, P. L., Hafler, D. A., Strominger, J. L., Byrne, M. C. (2000). Multiple differences in gene expression in regulatory Valpha 24Jalpha Q T cells from identical twins discordant for type I diabetes. Proc. Natl. Acad. Sci. USA 97: 7411-7416 [Abstract] [Full Text]  
• Naumov, Y. N., Bahjat, K. S., Gausling, R., Abraham, R., Exley, M. A., Koezuka, Y., Balk, S. B., Strominger, J. L., Clare-Salzer, M., Wilson, S. B. (2001). Activation of CD1d-restricted T cells protects NOD mice from developing diabetes by regulating dendritic cell subsets. Proc. Natl. Acad. Sci. USA 98: 13838-13843 [Abstract] [Full Text]  
• Pellicci, D. G., Hammond, K. J.L., Uldrich, A. P., Baxter, A. G., Smyth, M. J., Godfrey, D. I. (2002). A Natural Killer T (NKT) Cell Developmental Pathway Involving a Thymus-dependent NK1.1-CD4+ CD1d-dependent Precursor Stage. J. Exp. Med. 195: 835-844 [Abstract] [Full Text]  

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