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Vol. 204, No. 9, September 3, 2007. Pages 2171–2185.

Please note that the x axis labeling in Fig. 6 (D and E) was inadvertently cropped. The html and pdf versions are correct. The corrected figure is shown below.

View larger version (45K): [in this window] [in a new window] [Download PPT slide]   Figure 6. Effect of infection on CD4+ TEM cell differentiation from proliferating TCM cell precursors. (A) Schema of memory T cell differentiation in RMs (18). (B) The top profiles show CD4+ T cells from one RM with attenuated SIVmac239(nef) infection (PID 387; pvl = 5,200 copies/ml) and one with progressive SIVmac239 infection (PID 579; pvl = 3,800,000 copies/ml), indicating the gating of proliferating (Ki-67+) CD4+ memory T cells. The bottom profiles show the representation of TCM cells (CD28+; CCR5–) versus total TEM cells (including CD28+, CCR5+ transitional TEM cells, and CD28–/CCR5dim+ mature TEM cells) within the proliferating CD4+ memory compartment. (C) The figure shows cross-sectional analysis of the fractional representation of total TEM cells (as in A) in 10 SIV– RMs, 7 RMs with early plateau-phase SIVmac239 infection (PID 105; median pvl = 5,300,000 copies/ml), 8 RMs with late plateau-phase SIVmac239 infection (PID 533–878; median pvl = 660,000 copies/ml), and 12 RMs with controlled SIV infection: 9 infected with SIVmac239(nef) (PID 154–390; pvls < 400 copies/ml) and 3 spontaneous controllers of SIVmac239 (PID 105–147: pvls < 4,000 copies/ml). Differences were assessed by unpaired t test. (D) The profiles show the fractional representation of TEM cells among proliferating (Ki-67+) CD4+ memory T cells from PLNs from an RM 5 d before SIVmac239 infection, at PID 150 (immediately before ART; pvl = 4,400,000 copies/ml), and at 4 (pvl = 180,000) and 8 d (pvl = 87,000) after ART initiation. (E) The profiles show the fractional representation of TEM cells among proliferating (Ki-67+) CD4+ memory T cells from the blood of an SIVmac239-infected RM at PID 105 (immediately before ART; pvl = 3,000,000 copies/ml) and days 4 (pvl = 220,000 copies/ml), 10 (pvl = 170,000 copies/ml), and 17 (pvl = 24,000 copies/ml) after ART. The arrow indicates the development of a fully mature CD4+ TEM cell population.

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This Article Full Text (PDF) PPT slides of all figures Alert me when this article is cited Services Email this article Similar articles in this journal Alert me to new content in the JEM Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Okoye, A. Articles by Picker, L. J. Search for Related Content PubMed Articles by Okoye, A. Articles by Picker, L. J. Social Bookmarking                      What's this?