The Journal of Experimental Medicine
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Published online May 5, 2008
doi:10.1084/jem.20080569
The Journal of Experimental Medicine, Vol. 205, No. 5, 1003-1007
The Rockefeller University Press, 0022-1007 $30.00
© 2008 Allen et al.
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COMMENTARY

 Crippling HIV one mutation at a time

Todd M. Allen and Marcus Altfeld

T.M.A. and M.A. are at Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129

CORRESPONDENCE T.M.A.: tallen2{at}partners.org OR M.A.: maltfeld{at}partners.org


ABSTRACT
Accumulating data suggest that not all human immunodeficiency virus (HIV)-1–specific immune responses are equally effective at controlling HIV-1 replication. A new study now demonstrates that multiple immune-driven sequence polymorphisms in the highly conserved HIV-1 Gag region of transmitted viruses are associated with reduced viral replication in newly infected humans. These data suggest that targeting these and other conserved viral regions may be the key to developing an effective HIV-1 vaccine.


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Related Article

Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipients
Paul A. Goepfert, Wendy Lumm, Paul Farmer, Philippa Matthews, Andrew Prendergast, Jonathan M. Carlson, Cynthia A. Derdeyn, Jianming Tang, Richard A. Kaslow, Anju Bansal, Karina Yusim, David Heckerman, Joseph Mulenga, Susan Allen, Philip J.R. Goulder, and Eric Hunter
J. Exp. Med. 2008 205: 1009-1017. [Abstract] [Full Text] [PDF]





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