The Journal of Experimental Medicine
ThymUS '08
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Published online November 19, 2007
doi:10.1084/jem.20072371
The Journal of Experimental Medicine, Vol. 204, No. 12, 2785-2788
The Rockefeller University Press, 0022-1007 $30.00
© 2007 McMichael
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COMMENTARY

 Triple bypass: complicated paths to HIV escape

Andrew J. McMichael

A.J. McMichael is at MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK

CORRESPONDENCE A.J.M.: andrew.mcmichael{at}ndm.ox.ac.uk


ABSTRACT
Human immunodeficiency virus (HIV) type 1 is highly efficient at evading immune responses and persisting, ultimately causing fatal immunodeficiency in some patients. Mutation in the epitopes recognized by cytolytic CD8+ T cells (CTLs) is one such escape process. A new study now shows that one HIV-1 escape mutation may also result in impaired dendritic cell (DC) activity, possibly impairing later T cell responses to the same and other epitopes. The new data complete our understanding of the mechanisms by which the CTL response to an immunodominant gag epitope presented by human histocompatibility leukocyte antigen (HLA)-B27 is evaded. The complexity of the full escape helps to explain why patients with this HLA type progress to AIDS more slowly than average.


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J. Exp. Med. 2007 204: 2813-2824. [Abstract] [Full Text] [PDF]





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