The Journal of Experimental Medicine
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Published online April 28, 2008
doi:10.1084/jem.20070850
The Journal of Experimental Medicine
The Rockefeller University Press, 0022-1007 $30.00
© 2008 Smith-Bouvier et al.
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ARTICLE

 A role for sex chromosome complement in the female bias in autoimmune disease

Deborah L. Smith-Bouvier1, Anagha A. Divekar3, Manda Sasidhar1, Sienmi Du1, Seema K. Tiwari-Woodruff1, Jennifer K. King3, Arthur P. Arnold2, Ram Raj Singh3,4, and Rhonda R. Voskuhl1

1 Department of Neurology, 2 Department of Physiological Science, 3 Department of Medicine, Division of Rheumatology, and 4 Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, CA 90095

CORRESPONDENCE Rhonda R. Voskuhl: rvoskuhl{at}ucla.edu OR Ram R. Singh: RRSingh{at}mednet.ucla.edu

Most autoimmune diseases are more common in women than in men. This may be caused by differences in sex hormones, sex chromosomes, or both. In this study, we determined if there was a contribution of sex chromosomes to sex differences in susceptibility to two immunologically distinct disease models, experimental autoimmune encephalomyelitis (EAE) and pristane-induced lupus. Transgenic SJL mice were created to permit a comparison between XX and XY within a common gonadal type. Mice of the XX sex chromosome complement, as compared with XY, demonstrated greater susceptibility to both EAE and lupus. This is the first evidence that the XX sex chromosome complement, as compared with XY, confers greater susceptibility to autoimmune disease.

Abbreviations used: CNS, central nervous system; EAE, experimental autoimmune encephalomyelitis; LNC, LN cell; MOG, myelin oligodendrocyte glycoprotein; PLP, proteolipid protein.


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