The Journal of Experimental Medicine, Vol 99, 343-353,
Copyright, 1954, by The Rockefeller Institute for Medical Research New York
GLYCOGEN, AN IMMUNOLOGICALLY SPECIFIC POLYSACCHARIDE
Michael Heidelberger Ph.D.1,
Alan C. Aisenberg M.D.1,
William Z. Hassid Ph.D.1, and
With the Technical Assistance of Arnold Powell
1 From the Department of Medicine, College of Physicians and Surgeons, Columbia University, and the Presbyterian Hospital, New York, and the Department of Plant Biochemistry, University of California, Berkeley
Glycogens from various animal and vegetable sources precipitate antipneumococcal horse sera of Types II, VII, IX, XII, XX, and XXII.
Fractionated glycogen and glycogen recovered after reprecipitation, acetylation, and deacetylation precipitate the antisera, but glycogen degraded by saliva does not.
A fraction of the antibody is precipitated in the antisera by glycogen. Possible chemical relationships accounting for these instances of cross-precipitation are discussed in terms of the structures of glycogen and the type-specific polysaccharides of pneumococcus and the quantitative theory of specific precipitation.
Amylopectin also gives cross-reactions of smaller magnitude. Quantitative data on these are withheld until irregularities have been eliminated.
Submitted on December 25, 1953
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