The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 98, 277-289, Copyright, 1953, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE INFLUENCE OF CALCIUM IONS ON THE INACTIVATION OF HUMAN COMPLEMENT AND ITS COMPONENTS BY PLASMIN

Irwin H. Lepow Ph.D.1, Louis Pillemer Ph.D.1, Oscar D. Ratnoff M.D.1, and With the Technical Assistance of Leona Wurz

1 From the Institute of Pathology, Western Reserve University, the Department of Medicine, Western Reserve University School of Medicine, and the University Hospitals, Cleveland

Ca++ potentiates the inactivation of human complement by streptokinase-activated plasmin and chloroform-activated bovine plasmin. The optimum concentration of Ca++ varies between 10–2 M and 10–3 M, decreasing with increasing concentrations of streptokinase.

The susceptibility of the components of complement to inactivation by plasmin is different in the presence and absence of Ca++. C'2 and C'4 are most readily inactivated by plasmin in the presence of Ca++, while C'1 disappears first in the absence of Ca++. A large part of this C'1 disappearance is due to spontaneous inactivation.

Similarities are pointed out between the influence of Ca++ on the inactivation of the components of complement by antigen-antibody systems and by plasmin.

 Submitted on April 23, 1953


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