The Journal of Experimental Medicine
Avanti Polar Lipids
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The Journal of Experimental Medicine, Vol 97, 415-428, Copyright, 1953, by The Rockefeller Institute for Medical Research New York

ARTICLE

STUDIES ON RENAL JUXTAGLOMERULAR CELLS : I. VARIATIONS PRODUCED BY SODIUM CHLORIDE AND DESOXYCORTICOSTERONE ACETATE



Phyllis Merritt Hartroft 1 and W. Stanley Hartroft M.D.1

1 From the Banting and Best Department of Medical Research, University of Toronto, Canada

Accumulation of granules in the juxtaglomerular cells occurred in rats which were maintained for 5 to 6 weeks on a diet low in sodium, chloride. Cytological evidence suggests that this was probably a storage phase of secretion following a decrease in the rate of liberation of the granules. Administration of DCA (desoxycorticosterone acetate) to salt-deficient rats did not alter this appearance of the juxtaglomerular cells.

Two per cent sodium chloride taken in the drinking water consumed for 4 weeks by similar animals caused degranulation of the juxtaglomerular cells. This effect was enhanced by DCA. DCA administered to animals on a normal salt intake produced a lesser degree of degranulation. Cytological changes in degranulated cells suggested that these represent a stage of hyperactivity in the secretory cycle produced by an increase in the rate of liberation of granules.

A hypothesis is suggested that the juxtaglomerular cells are involved in the hormonal regulation of sodium metabolism and/or blood pressure.

 Submitted on October 28, 1952


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