The Journal of Experimental Medicine
ThymUS '08
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The Journal of Experimental Medicine, Vol 97, 139-144, Copyright, 1953, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE EFFECT OF X-RADIATION ON THE MULTIPLICATION OF RICKETTSIA MOOSERI IN EMBRYONATE EGGS

Donald Greiff Sc.D.1, Masahiro Chiga M.D.1, Herman T. Blumenthal M.D.1, and Henry Pinkerton M.D.1

1 From the Departments of Biology and Pathology, St. Louis University, and the Laboratory of the Jewish Hospital, St. Louis

The multiplication of Rickettsia mooseri in fertile eggs is speeded up and quantitatively increased by single dose x-radiation given either 24 hours before or 48 hours after inoculation. This effect is noted at all dosage levels studied, ranging from 100 to 1500 r. The rickettsiostatic effects of high incubation temperature (40°C.) and of streptomycin are neutralized by radiation, but the rickettsiostatic actions of PABA, penicillin, and aureomycin are not altered. Possible mechanisms of action and implications of the observed effects are discussed.

Submitted on September 5, 1952


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