The Journal of Experimental Medicine
Keystone Symposia
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Good, R. A.
Right arrow Articles by Thomas, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Good, R. A.
Right arrow Articles by Thomas, L.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
The Journal of Experimental Medicine, Vol 96, 625-641, Copyright, 1952, by The Rockefeller Institute for Medical Research New York

ARTICLE

STUDIES ON THE GENERALIZED SHWARTZMAN REACTION : II. THE PRODUCTION OF BILATERAL CORTICAL NECROSIS OF THE KIDNEYS BY A SINGLE INJECTION OF BACTERIAL TOXIN IN RABBITS PREVIOUSLY TREATED WITH THOROTRAST OR TRYPAN BLUE



Robert A. Good M.D.1 and Lewis Thomas M.D.1

1 From the Heart Hospital Research Laboratories and the Department of Pediatrics, University of Minnesota Medical School, Minneapolis

Intravenous injection of thorotrast or trypan blue rendered rabbits susceptible to the production of bilateral cortical necrosis of the kidneys by a single intravenous injection of small amounts of meningococcal or Serratia marcescens toxin. This reaction was not produced when thorotrast or trypan blue were injected after toxin had been given.

A single intradermal injection of toxin produced hemorrhagic skin lesions resembling the local Shwartzman reaction in rabbits given thorotrast 6 hours previously. These animals also developed bilateral cortical necrosis of the kidneys. When the order of injection was reversed, and thorotrast given after toxin, neither skin nor kidney lesions occurred.

The skin and kidney lesions in thorotrast-treated rabbits were, like the local and generalized Shwartzman reactions, completely prevented by treatment with nitrogen mustard, in doses sufficient to produce polymorphonuclear leukopenia.

The significance of these reactions, and their relationship to the previously described response to toxin in cortisone-treated rabbits, are discussed.

 Submitted on July 30, 1952


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?




  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS