The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 96, 499-512, Copyright, 1952, by The Rockefeller Institute for Medical Research New York

ARTICLE

TRANSAMINATION IN THE METABOLISM OF ß-2-THIENYL-DL-ALANINE IN NORMAL AND NEOPLASTIC CELLS IN VITRO

John A. Jacquez M.D.1, Ralph K. Barclay Ph.D.1, and C. Chester Stock Ph.D.1

1 From the Division of Experimental Chemotherapy, The Sloan-Kettering Institute for Cancer Research, New York

In tissue cultures of C-57 black mouse heart and sarcoma T-241, ß-2-thienyl-DL-alanine acts specifically as a phenylalanine antagonist.

Heart cultures can transaminate between ß-2-thienyl-DL-alanine and phenylpyruvate to form L-phenylalanine and thus block the toxic action of the remaining ß-2-thienyl-DL-alanine, whereas sarcoma T-241 cultures cannot.

Of eleven mouse tumors and four rat tumors tested for their ability to perform this reaction, nine tumors had little or no activity.

The ß-2-thienylpyruvic acid resulting from transamination further reacts to form a red compound the exact structure of which is not yet known.

 Submitted on July 1, 1952


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