The Journal of Experimental Medicine
Janeway's Immunobiology 7th Edition
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The Journal of Experimental Medicine, Vol 96, 491-497, Copyright, 1952, by The Rockefeller Institute for Medical Research New York

ARTICLE

ADAPTATION OF GROUP B COXSACKIE VIRUS TO ADULT MOUSE PANCREAS

Gilbert Dalldorf M.D.1 and Rebecca Gifford D.V.M.1

1 From the Division of Laboratories and Research, New York State Department of Health, Albany

An alteration of tissue tropism of a Coxsackie virus has been observed following different methods of propagation of the virus in animals.

Tropism for the adult mouse pancreas, as described by Pappenheimer, appeared to be irrevocably lost following prolonged brain-to-brain transfer.

It was present in the same strain on reisolation from human feces, was intensified following pancreas transfers, and suppressed by brain transfers.

Pancreatotropism may be correlated with the titer of virus in the pancreas.

 Submitted on June 28, 1952


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