The Journal of Experimental Medicine
Janeway's Immunobiology 7th Edition
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The Journal of Experimental Medicine, Vol 96, 121-136, Copyright, 1952, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE INTRACELLULAR DISTRIBUTION OF LANSING POLIOMYELITIS VIRUS IN THE CENTRAL NERVOUS SYSTEM OF INFECTED COTTON RATS

Carlton E. Schwerdt Ph.D.1 and Arthur B. Pardee Ph.D.1

1 From the Virus Laboratory, University of California, Berkeley

A procedure has been described for the centrifugal fractionation of the cellular particulate components of CNS tissue infected with poliomyelitis virus. A study of the distribution of infectivity among these components revealed that approximately four-fifths of the virus is found free in the submicroscopic particle fraction. The validity of the conclusion that the virus is located in this fraction of the intact neuron is discussed.

Submitted on April 24, 1952


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