The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 95, 465-472, Copyright, 1952, by The Rockefeller Institute for Medical Research New York

ARTICLE

AN ELECTROPHORETIC STUDY OF URINARY PROTEIN IN THE RAT

Alvin L. Sellers M.D.1, Sidney Roberts Ph.D.1, Irene Rask 1, Stephen Smith 3rd M.D.1, Jessie Marmorston M.D.1, and Howard C. Goodman M.D.1

1 From the Institute for Medical Research, Cedars of Lebanon Hospital, Department of Medicine, University of Southern California School of Medicine, and the Department of Physiological Chemistry, School of Medicine, University of California at Los Angeles

The nature of the proteins present in the urine of the normal rat has been investigated by electrophoretic analysis and by fractional precipitation of these proteins by ammonium sulfate. Components similar to serum alpha- and ß-globulin constitute the major portion of the urinary protein in both male and female rats.

Following the intraperitoneal injection of renin, a massive proteinuria occurs. The proteins excreted are similar in proportion and electric mobility to those of normal rat serum.

 Submitted on January 29, 1952


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