The Journal of Experimental Medicine
Avanti Polar Lipids
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The Journal of Experimental Medicine, Vol 93, 605-614, Copyright, 1951, by The Rockefeller Institute for Medical Research New York

ARTICLE

MECHANISM OF PROTEINURIA : IV. EFFECT OF RENIN ON HEMOGLOBIN EXCRETION



Richard W. Lippman M.D.1, Helen J. Ureen 1, and Jean Oliver M.D.1

1 From the Institute for Medical Research, Cedars of Lebanon Hospital, Los Angeles, and the Hoagland Laboratory, the Department of Pathology of the College of Medicine at the State University Medical Center, New York

1. Administration of renin to the rat causes an increase in the glomerular permeability to hemoglobin and a decrease in tubular absorption of this substance as measured by functional methods.

2. Morphologic examination in the rat and in the rabbit reveals an increased concentration of hemoglobin in the tubular lumina, confirmatory evidence of increased permeability. However, there is no significant effect upon the formation of hemoglobin droplets within the renal cells.

3. By analogy with the events observed in neutral red "secretion," it is suggested that hemoglobin is absorbed by both a "direct" and an "indirect" mechanism and that renin administration affects or depresses the "direct" mechanism only.

 Submitted on January 31, 1951


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