The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 93, 49-64, Copyright, 1951, by The Rockefeller Institute for Medical Research New York

ARTICLE

STUDIES ON THE MECHANISM OF THE SHWARTZMAN PHENOMENON : EVIDENCE FOR THE PARTICIPATION OF POLYMORPHONUCLEAR LEUCOCYTES IN THE PHENOMENON



Chandler A. Stetson M.D.1 and Robert A. Good M.D.1

1 From the Hospital of The Rockefeller Institute for Medical Research

The inhibition of the Shwartzman phenomenon by nitrogen mustard and benzene has been confirmed and investigated further.

This inhibition can be correlated with the leucopenia induced by these agents.

Evidence is presented indicating that polymorphonuclear leucocytes play an essential role in the preparation of the skin for the Shwartzman phenomenon.

 Submitted on August 28, 1950


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