The Journal of Experimental Medicine, Vol 93, 37-48,
Copyright, 1951, by The Rockefeller Institute for Medical Research New York
THE EFFECT OF CORTISONE AND ADRENOCORTICOTROPHIC HORMONE ON THE CONCENTRATION OF CIRCULATING ANTIBODY
Mogens Bjørneboe M.D.1,
Edward E. Fischel M.D.1, and
Herbert C. Stoerk M.D.1
1 From the Kommunehospitalet, Third (Medical) Department, Copenhagen, Denmark; the Department of Medicine, Columbia University College of Physicians and Surgeons, and The Edward Daniels Faulkner Arthritis Clinic of The Presbyterian Hospital, New York; and the Merck Institute for Therapeutic Research, Rahway
The administration of adrenocorticotrophic hormone and of cortisone was found to result in a reduction in the concentration of antipneumococcal antibody in the circulation of rabbits. This reduction occurred both when the hormones were administered at the beginning of immunization and after immunization was well advanced. Marked atrophic changes in lymphoid tissue and a diminution in the number of various types of mononuclear cells followed upon the hormone administration. The possible bearing of these observations on theories concerning the sites of antibody production is discussed.
Submitted on July 29, 1950