The Journal of Experimental Medicine
Keystone Symposia
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The Journal of Experimental Medicine, Vol 93, 1-12, Copyright, 1951, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE LYMPHOCYTIC ORIGIN OF A PLASMA FACTOR RESPONSIBLE FOR HYPERSENSITIVITY IN VITRO OF TUBERCULIN TYPE

Joseph M. Miller M.D.1, Cutting B. Favour M.D.1, and With the Technical Assistance of Merle A. Umbarger and Barbara A. Harrison

1 From the Medical Clinics, Peter Bent Brigham Hospital, and the Department of Medicine, Harvard Medical School, Boston,

Methods are described for the evaluation in vitro of the effect of tuberculin on the leucocytes of peripheral blood.

Washed leucocytes from a tuberculin sensitive host suspended in normal plasma are not lysed by tuberculin until after several hours of contact.

Washed leucocytes from a tuberculin-sensitive host slowly release into normal plasma a factor which will cause the lysis of normal leucocytes exposed to tuberculin.

Dialysis of normal plasma containing shed plasma factor causes the latter to precipitate with the euglobulins.

Shed plasma factor can be recovered from normal plasma which has been incubated with lymphocytes from tuberculin-sensitive hosts. Suspensions of neutrophils do not yield shed plasma factor.

 Submitted on July 27, 1950


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