The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 92, 499-505, Copyright, 1950, by The Rockefeller Institute for Medical Research New York

ARTICLE

IMMUNOLOGICAL REACTIONS OF THE COXSACKIE VIRUSES : III. CROSS-PROTECTION TESTS IN INFANT MICE BORN OF VACCINATED MOTHERS. TRANSFER OF IMMUNITY THROUGH THE MILK



Joseph L. Melnick Ph.D.1, Norman A. Clarke 1, and Lisbeth M. Kraft D.V.M.1

1 From the Section of Preventive Medicine, Yale University School of Medicine, New Haven

Maternal antibodies to the Coxsackie viruses (C virus) are conveyed to newborn mice through the colostrum and milk. of vaccinated mothers. No evidence for or against placental transmission of immunity was obtained.

The immunity conferred on the young is type-specific.

Immunity may be conferred to infants born of non-immune mice by allowing a suckling period of 24 to 48 hours with an immune mother.

Immunity appears to be transferred through the milk for the duration of lactation.

Strains of C virus can be typed by challenging infant mice born to mothers vaccinated with known types according to the outline presented above.

Complement-fixing antibodies are also transferred from vaccinated mother mice to their offspring.

 Submitted on July 14, 1950


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