The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 92, 121-128, Copyright, 1950, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE RENAL MECHANISM FOR URATE EXCRETION IN THE DALMATIAN COACH-HOUND

William Q. Wolfson M.D.1, Clarence Cohn M.D.1, and Clarice Shore 1

1 From the Department of Biochemistry, Medical Research Instittue, Michael Reese Hospital, Chicago

1. The renal mechanism for urate excretion in the Dalmatian dog resembles that in birds. Urate is cleared at a rate considerably greater than the glomerular filtration rate, indicating that its excretion is the result of both glomerular filtration and active tubular secretion. The basic physiological mechanisms involved in the anomalous purine metabolism of the Dalmatian are indicated and their possible biological significance briefly discussed.

2. A new enzymatic method for the direct estimation of true urate in biological fluids is described, which does not require the estimation of total urate and urate chromogen, followed by the calculation of true urate as a difference.

 Submitted on May 1, 1950


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