The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 92, 113-119, Copyright, 1950, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE EFFECT OF PODOPHYLLOTOXIN, COLCHICINE, URETHANE, AND NITROGEN MUSTARD ON THE RESPIRATION OF NORMAL AND SUPRARENALECTOMIZED RAT LYMPHATIC TISSUE

Zelma Baker Miller Ph.D.1, Clarke Davison 1, and Paul K. Smith Ph.D.1

1 From the Department of Pharmacology, The George Washington University School of Medicine, Washington, D.C.

The injection of podophyllotoxin, colchicine, and a nitrogen mustard derivative, methyl-bis(ß-chloroethyl)amine, into normal animals causes a reduction of the respiration of the lymphatic tissues, spleen, and/or thymus. No effect was demonstrable on kidney, a representative tissue of non-lymphatic origin.

The degree of inhibition was considerably less in suprarenalectomized animals, suggesting that the inhibition is mediated by the suprarenal gland.

 Submitted on April 7, 1950


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