The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 90, 267-272, Copyright, 1949, by The Rockefeller Institute for Medical Research New York

ARTICLE

NEPHROTOXIC NEPHRITIS IN RATS : EVIDENCE FOR THE GLOMERULAR ORIGIN OF THE KIDNEY ANTIGEN



David H. Solomon M.D.1, Joseph W. Gardella M.D.1, Herbert Fanger M.D.1, Frances M. Dethier 1, and Joseph W. Ferrebee M.D.1

1 From the Departments of Medicine and Pathology, Harvard Medical School, The Peter Bent Brigham Hospital, Boston, and the Mary Imogene Bassett Hospital, Cooperstown

Nephrotoxic anti-rat kidney sera were produced in rabbits by intraperitoneal injection of suspensions of blood-free rat kidney. The nephrotoxin of these sera could be removed by adsorption with saline suspensions of finely ground rat glomeruli, but not by adsorption with other portions of rat kidney or by adsorption with several other rat tissues. It was concluded that nephrotoxic sera of this type react primarily with glomerular tissue and, by inference, that the antigen essential for the production of these anti-kidney sera was of glomerular origin.

The observations are consistent with Pressman's (15, 16) demonstration that anti-mouse kidney sera labeled with radioiodine localize primarily in glomeruli.

 Submitted on May 31, 1949


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