The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 90, 225-232, Copyright, 1949, by The Rockefeller Institute for Medical Research New York

ARTICLE

SEQUENCES IN THE FORMATION OF CLOTS FROM PURIFIED BOVINE FIBRINOGEN AND THROMBIN: A STUDY WITH THE ELECTRON MICROSCOPE

Keith R. Porter Ph.D.1 and Clinton Van Zandt Hawn M.D.1

1 From the Laboratories of The Rockefeller Institute for Medical Research, New York, and The Mary Imogene Bassett Hospital, Cooperstown, New York

The observed sequences in the formation of clots from purified bovine fibrinogen and thrombin are described. Under the conditions of these experiments, it appears that fibrinogen molecules are polymerized by the action of thrombin to form needle-shaped, crystal-like protofibrils which then become aligned into fiber strands by lateral association. The integrity of the unit fibrils is maintained within the strand.

A model of the fibrinogen molecule is proposed which may satisfy the reported physical constants, data from x-ray diffraction studies, and observations made upon electron micrographs.

 Submitted on May 5, 1949


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