The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 90, 195-212, Copyright, 1949, by The Rockefeller Institute for Medical Research New York

ARTICLE

A MURINE VIRUS (JHM) CAUSING DISSEMINATED ENCEPHALOMYELITIS WITH EXTENSIVE DESTRUCTION OF MYELIN : II. PATHOLOGY



Orville T. Bailey M.D.1, Alwin M. Pappenheimer M. D.1, F. Sargent Cheever M.D.1, and Joan B. Daniels 1

1 From the Departments of Bacteriology and Pathology, Harvard Medical School, the Neurological Institute of the Children's Hospital, and the Massachusetts Department of Public Health, Boston

A description has been given of the pathologic changes produced experimentally in animals by the inoculation of a virus material obtained from a mouse with spontaneous encephalomyelitis. The most distinctive feature of the lesions in the central nervous system is the widespread destruction of myelin. Giant cells derived from a variety of tissue elements characterize the early lesions. The liver in the majority of cases is the seat of focal necrosis. In some mice, infected with large doses by the intravenous route, there is produced massive necrosis of the liver, with fat infiltration and calcification. Giant cells are occasionally found in lymphatic tissue, but no significant changes were noted in other organs. Inclusions or elementary bodies were not demonstrated in the lesions.

Similar lesions were produced by the inoculation of mouse virus into hamsters. In rats, the lesions were of a more chronic character.

The relation of this disease to other demyelinating diseases of man and animals is discussed.

 Submitted on May 15, 1949


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