The Journal of Experimental Medicine
Avanti Polar Lipids
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The Journal of Experimental Medicine, Vol 90, 147-156, Copyright, 1949, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE INFLUENCE OF DIET ON IRON ABSORPTION : II. THE INTERRELATION OF IRON AND PHOSPHORUS



D. Mark Hegsted Ph.D.1, Clement A. Finch M.D.1, and Thomas D. Kinney M.D.1

1 From the Department of Nutrition, Harvard School of Public Health, the Departments of Biological Chemistry and Pathology, Harvard Medical School; the Departments of Pathology and Medicine, Peter Bent Brigham Hospital, Boston; the Departments of Pathology of Western Reserve University School of Medicine and Cleveland City Hospital, Cleveland; and the Department of Physics, Massachusetts Institute of Technology, Cambridge

Rats fed a corn grit diet containing large amounts of ferric citrate absorb and deposit excessive amounts of iron in their livers. Undoubtedly various factors are involved in iron absorption, but these studies indicate that the low level of dietary phosphate was primarily responsible.

The addition of phosphate salts to this diet has shown that the amount of iron deposited in the liver was inversely related to the phosphorus content of the diet.

It is possible to obtain excessive iron deposits in the livers of animals receiving a normal diet, by adding large amounts of iron salts to the diet. This is not associated with losses of body weight in these animals.

It is concluded that the absolute amount of iron and/or phosphorus in the diet as well as the iron-phosphorus ratio influences the amount of iron absorbed.

 Submitted on April 11, 1949


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