The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 90, 137-146, Copyright, 1949, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE INFLUENCE OF DIET ON IRON ABSORPTION : I. THE PATHOLOGY OF IRON EXCESS



Thomas D. Kinney M.D.1, D. Mark Hegsted Ph.D.1, and Clement A. Finch M.D.1

1 From the Departments of Pathology, Biological Chemistry, and Medicine, Harvard Medical School, the Department of Nutrition, Harvard School of Public Health; the Departments of Pathology and Medicine, Peter Bent Brigham Hospital, Boston; the Departments of Pathology of Western Reserve University School of Medicine and Cleveland City Hospital, Cleveland; and the Department of Physics, Massachusetts Institute of Technology, Cambridge

Rats placed on a corn grit diet and added iron absorbed large amounts of iron in contrast to control groups.

The histological picture was that of progressive hemosiderosis of the hepatic parenchyma and of the reticuloendothelial system. On chemical analysis, the iron content of the liver was found to be greatly increased. This supports the concept that the liver represents the chief storage organ for iron so absorbed.

These data indicate that a normal block for iron absorption may be overcome under certain circumstances.

 Submitted on January 30, 1949


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