The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 90, 53-72, Copyright, 1949, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE RÔLE OF THE "WAX" OF THE TUBERCLE BACILLUS IN ESTABLISHING DELAYED HYPERSENSITIVITY : II. HYPERSENSITIVITY TO A PROTEIN ANTIGEN, EGG ALBUMIN



Sidney Raffel M.D.1, Louis E. Arnaud 1, C. Dean Dukes Ph.D.1, and Jwo S. Huang 1

1 From the Department of Bacteriology and Experimental Pathology, School of Medicine, Stanford University, Stanford

Guinea pigs sensitized with egg albumin along with the purified wax fraction of the human tubercle bacillus respond with delayed hypersensitive reactivity to the protein antigen. Previous publications have reported a similar activity of the wax with respect to tuberculoprotein and picryl chloride. The effect is not referable to an ordinary adjuvant activity of the bacillary wax, since antibody titers are not increased in animals which receive it, and since a known adjuvant, water-in-oil emulsion, has no effect with respect to the induction of delayed hypersensitivity.

This report further extends the rôle of the tubercle bacillary wax in the induction of delayed hypersensitive states.

 Submitted on March 4, 1949


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