The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 89, 631-641, Copyright, 1949, by The Rockefeller Institute for Medical Research New York

ARTICLE

OBSERVATIONS ON THE RÔLE OF THE RAT KIDNEY IN HYPERTENSION CAUSED BY DESOXYCORTICOSTERONE ACETATE

Sydney M. Friedman M.D.1 and Constance L. Friedman Ph.D.1

1 From the Department of Anatomy, McGill University, Montreal

Desoxycorticosterone acetate in pellet form was administered for 51 days to albino rats of the Sherman strain which also received 1 per cent saline as drinking water. Treatment was stopped in representative groups at 25, 37, and 51 days so that the regression of blood pressure and renal changes could be observed. It was noted that both the elevation in blood pressure during treatment and its reversal when treatment was stopped were closely correlated with corresponding changes in renal mass. In the time for which the process was studied it did not become irreversible.

Removal of both kidneys from DCA-treated animals aggravated the hypertension, suggesting that the kidneys are actively concerned with the excretion and possible inactivation of the steroid.

 Submitted on November 24, 1948


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