IMMOBILIZATION OF TREPONEMA PALLIDUM IN VITRO BY ANTIBODY PRODUCED IN SYPHILITIC INFECTION

doi:10.1084/jem.89.4.369

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The Journal of Experimental Medicine, Vol 89, 369-393, Copyright, 1949, by The Rockefeller Institute for Medical Research New York

ARTICLE

IMMOBILIZATION OF TREPONEMA PALLIDUM IN VITRO BY ANTIBODY PRODUCED IN SYPHILITIC INFECTION

Robert A. Nelson Jr. M.D.¹, Manfred M. Mayer Ph.D.¹, and With the Assistance of Judith A. Diesendruck, Sc.D., and John T. Eagan

¹ From the Department of Bacteriology of The Johns Hopkins School of Hygiene and Public Health, Baltimore

Treponema pallida were extracted from rabbit testicular syphilomasand suspended in a special medium in which the organisms remainmotile and infectious for several days. On incubation of suchsuspensions with syphilitic rabbit or human sera and guineapig complement, the treponemes became non-motile and lost theircapacity to infect rabbits. Various factors affecting this immobilizationhave been investigated.

In a preliminary survey of individualsera, immobilizing antibody could be detected in the majorityof sera from syphilitic animals and human beings, but was absentin almost all the normal sera examined.

It could be demonstratedthat the immobilizing and reagin activities of syphilis seraare due to separate antibodies.

Submitted on October 25, 1948

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