The Journal of Experimental Medicine, Vol 89, 175-184,
Copyright, 1949, by The Rockefeller Institute for Medical Research New York
THE EFFECT OF DIET ON THE SUSCEPTIBILITY OF THE MOUSE TO PNEUMONIA VIRUS OF MICE (PVM)
:
II. INFLUENCE OF PYRIDOXINE ADMINISTERED IN THE PERIOD BEFORE AS WELL AS AFTER THE INOCULATION OF VIRUS
George S. Mirick M.D.1,
William B. Leftwich M.D.1, and
With the Technical Assistance of Miss Elizabeth I. Corddry
1 From the Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore
Young mice fed diets deficient in pyridoxine for 8 days or longer before the inoculation of PVM, as well as after inoculation, were more susceptible to infection than control mice fed complete diets.
Young mice fed a pyridoxine-deficient diet gained weight as well as controls fed a complete diet for 5 weeks, but they lost weight in the 6th week.
The ratio of thymus or spleen weight to body weight was less in mice fed a pyridoxine-deficient diet for 6 weeks than in controls fed a complete diet. Histologically the thymuses and spleens showed hypoplasia.
No measurable difference in antibodies against PVM was found in the sera of uninoculated mice fed complete or pyridoxine-deficient diets for 6 weeks.
Submitted on November 2, 1948
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