The Journal of Experimental Medicine
Randox clinical diagnostic solutions
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The Journal of Experimental Medicine, Vol 89, 131-140, Copyright, 1949, by The Rockefeller Institute for Medical Research New York

ARTICLE

RENIN PROTEINURIA IN THE RAT : I. THE RELATION BETWEEN THE PROTEINURIA AND THE PRESSOR EFFECT OF RENIN



T. Addis M.D.1, Evalyn Barrett 1, Robert I. Boyd M.D.1, and Helen J. Ureen 1

1 From the Department of Medicine, Stanford University Medical School, San Francisco

In the rat renin induces an intense but transient proteinuria, associated with the excretion of fibrinogen but not accompanied by any evidence of damage to the glomerulus.

The inactivation of renin with respect to its pressor effect leads to a loss of its capacity to induce proteinuria.

Angiotonin, when given in large amounts, induces proteinuria in the rat.

It is concluded that this form of proteinuria is dependent on the pressor action of renin.

 Submitted on October 29, 1948


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