The Journal of Experimental Medicine, Vol 88, 645-654,
Copyright, 1948, by The Rockefeller Institute for Medical Research New York
THE SUSCEPTIBILITY OF THE HAMSTER TO MOUSE ENCEPHALOMYELITIS VIRUS
Donald J. Dean D.V.M.1 and
Gilbert Dalldorf M.D.1
1 From the Division of Laboratories and Research, New York State Department of Health, Albany
The OT strain of mouse encephalomyelitis virus induces an inapparent infection in suckling hamsters associated with lesions of the central nervous system and skeletal muscles. The virus increases in pathogenicity after alternating mouse-hamster transfers and then induces both paralysis and encephalitis. Pathogenicity is lost through serial hamster passages but is restored by a single mouse transfer.
Submitted on September 1, 1948