The Journal of Experimental Medicine
StemCell Technologies
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The Journal of Experimental Medicine, Vol 88, 521-528, Copyright, 1948, by The Rockefeller Institute for Medical Research New York

ARTICLE

SPECIFIC SERUM AGGLUTINATION OF ERYTHROCYTES SENSITIZED WITH EXTRACTS OF TUBERCLE BACILLI

Gardner Middlebrook M.D.1 and René J. Dubos Ph.D.1

1 From the Laboratories of The Rockefeller Institute for Medical Research

A hemagglutination reaction has been described between sheep erythrocytes treated with a component of a polysaccharide fraction of mammalian tubercle bacilli and the sera of experimental animals or of tuberculous patients.

Evidence has been presented for the specificity of this reaction. A modification of the test, involving an inhibition reaction, has been developed for the detection and quantitation of minute amounts of the material responsible for the hemagglutination reaction.

 Submitted on August 10, 1948


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