The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 88, 65-72, Copyright, 1948, by The Rockefeller Institute for Medical Research New York

ARTICLE

POLIOMYELITIS IN THE CYNOMOLGUS MONKEY : IV. FURTHER OBSERVATIONS ON EXPOSURES CONFINED TO THE STOMACH AND INTESTINES, WITH NOTES ON THE FECAL EXCRETION OF VIRUS



Harold K. Faber M.D.1, Rosalie J. Silverberg 1, and Luther Dong 1

1 From the Department of Pediatrics, Stanford University School of Medicine, San Francisco

36 exposures of the stomach and intestines of 18 cynomolgus monkeys to large doses of poliomyelitis virus by a method designed to avoid simultaneous exposure of the oropharynx and upper esophagus induced poliomyelitis in only one instance.

These observations are to be compared with a previous study in which exposures of the entire alimentary tract including oropharynx and upper esophagus by simple feeding of comparable amounts of the same strain resulted in poliomyelitis in half of the test animals.

In the capsule-fed animals virus regularly appeared in the stools during and immediately after the feeding periods but disappeared thereafter excepting in the single case of poliomyelitis, in which it persisted.

No evidence of resistance to subsequent intracerebral inoculation was observed in the uninfected capsule-fed animals.

 Submitted on March 25, 1948


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