The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 87, 489-501, Copyright, 1948, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE EFFECT OF NITROGEN MUSTARDS ON ENZYMES AND TISSUE METABOLISM : I. THE EFFECT ON ENZYMES



E. S. Guzman Barron M.D.1, Grant R. Bartlett Ph.D.1, and Zelma Baker Miller Ph.D.1

1 From the Chemical Division, Department of Medicine, The University of Chicago, Chicago

Nitrogen mustards are powerful inhibitors for choline oxidase, acetylcholine esterase, and choline acetylase, half-inhibition of the first enzyme being produced with concentrations around 1 x 10–6 M; i.e., ten times less than the LD50 values. Acetylcholine esterase and choline acetylase required higher concentrations. This inhibition seems to be due to the structural similarity of the ethylenimonium derivatives with choline and acetylcholine. A list of enzyme systems inhibited by nitrogen mustards is given.

Submitted on February 25, 1948


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