The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 87, 21-27, Copyright, 1948, by The Rockefeller Institute for Medical Research New York

ARTICLE

STUDIES OF THE DISTRIBUTION OF POLIOMYELITIS VIRUS : V. THE VIRUS IN FAMILIAL ASSOCIATES OF CASES



Gordon C. Brown Sc.D.1, Thomas Francis Jr. M.D.1, and John Ainslie M.D.1

1 From the Department of Epidemiology and the Virus Laboratory, School of Public Health, University of Michigan, Ann Arbor

The occurrence and duration of the carrier state in familial associates of recognized cases of poliomyelitis was studied by the examination for virus of stool specimens collected from the members of four families at regular intervals for a period of over 2 months. The results indicate that: (1) virus may persist in their stools continuously for 4 to 5 weeks; (2) virus may be encountered intermittently in the stools; (3) in some instances virus may be present for brief periods only; (4) children are more likely to maintain virus than are adults in the same family; (5) infection of a family takes place rapidly, suggesting again simultaneous infection from a common source.

Submitted on September 18, 1947


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