The Journal of Experimental Medicine
Fluorescence In Vivo Endomicroscopy
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The Journal of Experimental Medicine, Vol 86, 117-124, Copyright, 1947, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE MORPHOLOGY AND BEHAVIOR OF NEOPLASTIC MAST CELLS CULTIVATED IN VITRO

George H. Paff Ph.D.1, Frank Bloom D.V.M.1, and Christopher Reilly 1

1 From the Departments of Anatomy and Pathology of the Long Island College of Medicine, Brooklyn

Fragments from two mast cell tumors of the dog have been cultured in vitro. Studies on the living and on fixed and stained preparations revealed the following:

Only mast cells grew out from the original tumor fragments though these contained other types of cells. They grew in some of the roller tube cultures in a sheet resembling an epithelium but in hanging drop cultures they lay separate and were irregularly spindle or star-shaped with long protoplasmic processes.

The cytoplasmic granules of the proliferating mast cells varied in size, number, and tinctorial properties. In most of the cells they stained metachromatically, in occasional cells some of the granules only could be stained, and in a few none could be stained.

 Submitted on February 17, 1947


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