The Journal of Experimental Medicine
ThymUS '08
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cohen, S. S.
Right arrow Articles by Fowler, C. B.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Cohen, S. S.
Right arrow Articles by Fowler, C. B.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
The Journal of Experimental Medicine, Vol 85, 771-784, Copyright, 1947, by The Rockefeller Institute for Medical Research New York

ARTICLE

CHEMICAL STUDIES ON HOST-VIRUS INTERACTIONS : III. TRYPTOPHANE REQUIREMENTS IN THE STAGES OF VIRUS MULTIPLICATION IN THE ESCHERICHIA COLI-T2 BACTERIOPHAGE SYSTEM



Seymour S. Cohen Ph.D.1 and Catherine B. Fowler 1

1 From The Children's Hospital of Philadelphia (Department of Pediatrics), and the Department of Physiological Chemistry, University of Pennsylvania, School of Medicine, Philadelphia

The inhibition of virus multiplication by 5-methyl tryptophane can be specifically reversed by tryptophane. The conditions of reversal indicate that 5MT specifically interferes with tryptophane utilization. The tryptophane requirements of virus multiplication appear to exist throughout the latent period and determine the time of lysis and amount of virus liberated. A latent period may be interrupted for 15 minutes or more and be resumed on addition of tryptophane. Extended inhibition with 5MT results in a somewhat variable "killing" effect, the extent of which determines aspects of the reversal of the inhibition by tryptophane. The implications of these phenomena have been discussed.

Submitted on March 17, 1947


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:



  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS