The Journal of Experimental Medicine
Keystone Symposia
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The Journal of Experimental Medicine, Vol 85, 405-416, Copyright, 1947, by The Rockefeller Institute for Medical Research New York

ARTICLE

EPIDEMIC DIARRHEAL DISEASE OF SUCKLING MICE : I. MANIFESTATIONS, EPIDEMIOLOGY, AND ATTEMPTS TO TRANSMIT THE DISEASE



F. Sargent Cheever M.D.1 and J. Howard Mueller Ph.D.1

1 From the Department of Bacteriology and Immunology, Harvard Medical School and School of Public Health, Boston

1. The disease was almost certainly infectious.

2. Its eradication offered much greater practical difficulties than are presented by certain other infections of mice.

3. A definite tendency toward greater susceptibility in first litters as contrasted with subsequent ones was noted.

4. Advantage could be taken of this increasing resistance to keep the infected colony in efficient production, but accidental loss of the stock prevented the continuation of the plan for a time sufficient to exclude possible failure due to seasonal variation.

5. Multiple etiologies may well have existed even within this circumscribed outbreak.

6. Experimental investigation of the condition offers extraordinary difficulties but its thorough understanding promises to bring new light to basic problems of disease.

 Submitted on October 16, 1946


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