The Journal of Experimental Medicine
Avanti Polar Lipids
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The Journal of Experimental Medicine, Vol 85, 365-371, Copyright, 1947, by The Rockefeller Institute for Medical Research New York

ARTICLE

IMPAIRMENT OF ANTIBODY RESPONSE IN PYRIDOXINE-DEFICIENT RATS

Herbert C. Stoerk M.D.1, Herman N. Eisen M.D.1, and Hedda M. John M.D.1

1 From the Department of Pathology, College of Physicians and Surgeons, Columbia University, New York

Striking impairment of the antibody response to sheep erythrocytes was found in pyridoxine-deficient rats. Deficiencies in the three other B factors required by the rat, and low protein feeding, having effects on body weight comparable to pyridoxine deficiency, failed to influence the antibody response studied.

Confirming previous observations, a striking loss of thymic and lymphoid tissue occurred in the pyridoxine-deficient animals. A marked deficit in thymus weight also resulted from the feeding of a diet low in thiamin. Histologically, however, lymphoid atrophy was less pronounced in thiamin-deficient rats than in those deprived of pyridoxine.

 Submitted on October 13, 1946


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