The Journal of Experimental Medicine
Torrey Pines Biolabs
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The Journal of Experimental Medicine, Vol 84, 535-548, Copyright, 1946, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE ACTIVATING EFFECT OF MAGNESIUM AND OTHER CATIONS ON THE HEMOLYTIC FUNCTION OF COMPLEMENT

Manfred M. Mayer Ph.D.1, Abraham G. Osler 1, Otto G. Bier M.D.1, and Michael Heidelberger Ph.D.1

1 From the Department of Medicine, College of Physicians and Surgeons, Columbia University, and the Presbyterian Hospital, New York

1. The evidence presented indicates that Mg++, or other cation such as Ca++, Ni++, or Co++, is essential for the hemolytic action of C'. Ca++, Ni++, and Co++ are less effective than Mg++. The hemolytic system usually does not contain sufficient Mg++ for optimal hemolytic activity so that a marked enhancement can be obtained by addition of extra Mg++.

2. The enhancing action of tissue fluids can be ascribed to their contribution of Mg++.

3. Substances which bind Mg++ and Ca++ are anticomplementary when added to the usual hemolytic system which contains only a small quantity of Mg++. This type of anticomplementary effect can be overcome by addition of extra Mg++.

4. Ca++ may also be essential to the lytic process but its action is much less pronounced than that of Mg++.

 Submitted on July 9, 1946


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